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Название : 3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening
Автор : William S. Kisaalita
Издательство: CRC Press
Год издания : 2010
Страниц: 404
Формат : PDF
Размер файла: 5,4 MB
Язык : English
The book supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm. The author uses results from his lab and those of other investigators to show how 3D micro environments create cell culture models that more closely reflect normal in vivo-like cell morphology and function. He makes a case for validated biomarkers for three-dimensionality in vitro and discusses the advantages and disadvantages of promising tools in the search of these biomarkers. The book concludes with case studies of drugs that were abandoned late in the discovery process, which would have been discarded early if tested with 3D cultures.
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