Structural Genomics (General Applications)

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Автор: Yu Wai Chen

Название: Structural Genomics (General Applications)

Издательство: Humana Press

Год: 2014

Формат: pdf

Размер: 7.8Mb

Язык: Английский

The topics are grouped under three parts: (I) the cloning and production of proteins

for structural studies, (II) experimental methods and (III) computational methods and data analysis. Half of this book is devoted to the fi rst part, as recombinant protein production remains a major bottleneck in many structural projects. For experimental methods, I intentionally brought in a range of complementary technologies. As a result of high-throughput practices, structural data is generated at an ever-increasing rate. This calls for improved quality control and creative computational tools for data interpretation and visualisation—these topics are grouped into the third part. Overall, the spectrum of topics refl ects the trend towards tackling more ambitious challenges of studying macromolecular machineries and complexes.