In vivo models for drug discovery

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Автор: Vela, José; Maldonado, Rafael; Hamon, Michel; Adnot, Serge

Название: In vivo models for drug discovery

Язык: английский

Издательство: Weinheim, Germany: Wiley-VCH

Год: 2014

Объем: 594 p.

Формат: pdf

Размер: 18,1 mb

This one-stop reference presents the complete picture - covering all relevant organisms and physiological functions, from single cells to mammals, as well as all major disease areas.

This handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects.

After a general introduction to the topic, the expert contributors discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine, gastro-intestinal, urogenital disorders, cancer, migraine and chronic pain, and from infectious to neuropsychiatric diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges.

Key knowledge for drug researchers in industry as well as academia.

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