Semaphorins: A Diversity of Emerging Physiological and Pathological Activities

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Автор:Atsushi Kumanogoh

Название: Semaphorins

Год:2015

Издательство:Springer

Формат:PDF

Размер:5.6 mb

Страниц:226

Язык:English

This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders.